Metronidazole reduction occurs via ferredoxin-mediated electron transport
Ferredoxin, Fd, is often deficient in metronidazole-resistant strains of Trichomonas vaginalis and is thought to be necessary for drug activation
Two hydrogenosomal
The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of metronidazole by Fd to toxic
21-fold) and an increase in suggesting that there was a decline in the formation of covalent adducts that occurs with activated metronidazole
Metronidazole Injection, USP, in 100 mL VIAFLEX Plus single dose plastic container, is
Clostridium pasteurianum cell-free extracts enzymatically reduced metronidazole when coupled by hydrogenase via reduced ferredoxin
In these organisms, ferredoxin, which is being reduced by pyruvate:ferredoxin oxidoreductase (PFOR), has been suggested to activate metronidazole
Metronidazole, or Flagyl, is a drug used in the treatment of trichomoniasis, amebiasis, and anaerobic bacterial infections
during the 1950s
The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm
In G
In trichomonads, the fermentative carbohy-drate metabolism involved in drug activation is compart- In this study, we show that, in E
Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance