Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and non-linear pharmacokinetics
Phenytoin sodium is an antiepileptic drug
Phenytoin Pharmacokinetics Absorption Bioavailability
Therefore, both phenytoin and fosphenytoin have been used for second-line therapy of SE from 2011 to 2015
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TLDR
It is an effective anticonvulsant for the chronic treatment of tonic-clonic (grand mal) or partial seizures and the acute treatment of generalized status epilepticus ( Table 10-1 )
Children older than 6 years of age—300 mg per day
Because phenytoin sodium is insoluble and its pH is high (pH 12), administration of this medication could cause pain, swelling, tissue necrosis, and other side effects at the injection site
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Phenytoin sodium is an antiepileptic drug
a prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam – Pilot study
1 mL in Water for Injection