72) Conclusions: Patients treated with nicardipine are more likely to reach the physician-specified SBP target range within 30 minutes than those treated with labetalol
All antihypertensive medication can potentially cross the placenta
Patients were eligible if they had a diagnosis of an acute stroke and were administered either CIV-labetalol or CIV-nicardipine
The preferred agents include labetalol, esmolol, nicardipine, and fenoldopam
98–6
[Am J Emerg Med
Labetalol was found to have a shorter time to goal BP as compared to nicardipine (24 min vs
Abstract
Food and Drug Administration (FDA)-recommended doses of labetalol and
Labetalol and nicardipine are often used for acute hypertension but there are little data comparing the two
Similar results were found in a study
• Overshoot of BP below the specified range occurred in less than 15% of patients treated with either nicardipine or labetalol
Methods: A retrospective chart review was conducted to identify patients who received labetalol, nicardipine, or hydralazine to treat elevated blood Labetalol or esmolol in combination with nitroglycerin (up to 60 μg/min) Hypertensive encephalopathy: Labetalol, nicardipine, or fenoldopam: Acute aortic dissection: Labetalol or combination of nicardipine or fenoldopam and esmolol or combination of nitroprusside with either esmolol or intravenous metoprolol: Eclampsia:
Duration of effect 2-4 hr
4%); and 189
Clonidine and angiotensin-converting enzyme (ACE) inhibitors are long acting and poorly titratable
Reported side effects include hypotension, bradycardia nausea, vomiting, scalp tingling, and burning sensation in the groin
Nicardipine infusion, 5 mg/h, titrate up to desired effect by Increasing 2
Effect of interaction is not clear, use caution
Labetalol and nicardipine are recommended by the American Heart Association/American 3
40–1
Nicardipine
No patient had any episode of hypotension
There were 81 patients (95
In addition, nicardipine was associated with a more rapid response to therapy (F = 8
Nicardipine Versus Labetalol