Take it as directed on the prescription label at the same time every day
Drugs and Lactation Database (LactMed®) Bethesda (MD): National Institute of Child Health and Human Development; 2006 -
Lactation
1
Spironolactone oral suspension is an antagonist of aldosterone indicated for: the treatment of NYHA Class III-IV heart failure and reduced ejection fraction to
Lowering blood pressure can reduce the risk of strokes and heart attacks
It is not known whether unmetabolised spironolactone is excreted into breast milk
ALDACTONE is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure (1
Canrenone, which is the principle metabolite, is excreted into human milk and has been found with a milk: plasma ratio of 0
Maternal Levels
It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body
4 Primary Hyperaldosteronism Spironolactone tablets are indicated in the following Hypertension (defined in this topic as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg), is a common complication of pregnancy and the incidence is increasing [ 1,2 ]
Lactation
Spironolactone is well absorbed orally and is principally metabolised to active metabolites: sulfur containing metabolites (80%) and partly
The original study provided enough data to calculate that the babies were receiving between 2-4% of the mother's medication in the breastmilk
Maintenance dose: Patients tolerant of initial dose: May increase to 50 mg orally once a day as clinically indicated
Consider the developmental and health benefits of breastfeeding along with the mother's clinical need for spironolactone and any potential adverse effects on the breastfed child from spironolactone or from the underlying maternal condition
Pregnancy and Lactation
The patient continued to partially breastfeed the infant for at least 6 months
Spironolactone is a potassium-sparing medication used as a diuretic medication for heart failure, liver disease and high blood pressure