A prospective study of 764 Vietnamese adults with tuberculous meningitis who were HIV-negative and treated with dexamethasone reported that presence of
However, there is no universally accepted regimen
Early intravenous administration of glucocorticoids (usually dexamethasone) has been evaluated as adjuvant therapy in an attempt to diminish the rate of hearing
The recommended steroids are dexamethasone and prednisolone 63
Investigators in Vietnam and Indonesia evaluated adjunctive dexamethasone in PLWH who had definite, probable, or possible TB meningitis
In one randomized, controlled study 55 involving 47 patients in India, dexamethasone was found to be useful as an adjunct treatment in cases of tuberculous meningitis, especially in patients with The standard duration of antimicrobial therapy for an uncomplicated case at the participating institutions is seven to 10 days for H influenzae, five to seven days for N meningitidis, seven to 14 days for S During the present study the results of another similar randomized controlled trial of dexamethasone in meningitis were published Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults
8, – 12 Delays in seeking medical care, diagnosis, and initiation of treatment are contributing Duration of therapy (days) than six weeks with suspected bacterial meningitis
We examined the evidence published up to 18 March 2016 and included nine trials with 1337 people that evaluated either dexamethasone, methylprednisolone, or prednisolone given in addition Objective: This study aimed to systematically evaluate the clinical efficacy of dexamethasone in patients with tuberculous meningitis (TBM) through meta-analysis
A prospective study of 764 Vietnamese adults with tuberculous meningitis who were HIV-negative and treated with dexamethasone reported that presence of inflammatory markers in CSF and fatality rates were predicted by LTA4H genotype (fatality in 3 [7%] of 42 patients with TT genotype [ie, high inflammatory variant], 40 [21%] of 187
Dexamethasone is used for the treatment of suspected bacterial meningitis, A but is not licensed for this indication
Suggested duration of antibacterial treatment 10 days
J
To the Editor: The results of the placebo-controlled clinical trial of adjunctive dexamethasone in the treatment of tuberculous meningitis reported by Thwaites et al
Tuberculous meningitis is a serious complication caused by Mycobacterium tuberculosis