GSH is a sensitive indicator of oxidative stress, and GSH levels in the diabetic mice were significantly less ( Fig
4 ± 1
Oxaloacetate, upon entering the Krebs cycle, generates electron donors, FADH 2 and NADH, which are
Oct 28, 2021 · The neuroprotective effect of topiramate on the ultrastructural picture of the synapses was demonstrated mainly by less substantial swelling of the synaptic endings
Mar 25, 2019 · brain mitochondria was found to be comparable to the action of cyclosporin A
6-fold to 1
Topiramate enhances GABA (A) receptor activity, which enhances inhibitory effects
Since mitochondria are intimately involved in pathways leading to pyramidal cell death in epilepsy we evaluated putative effects of topiramate on mitochondrial function in the rat
Sep 7, 2023 · Effect of Topiramate on Mitochondrial Biogenesis and Neuroinflammation in Chronic Constriction Injury and Streptozotocin-induced Peripheral Neuropathy Abdulla K
1 day ago · The topiramate groups saw their weight drop from 4
Furthermore, TPM could inhibit CAs, which was important for lipogenesis in the mitochondria and cytosol [Scozzafava A
Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines
Although Here's the procedure: Get the teaspoon of food ready
Affected mitochondrial oxidative phosphorylation to induce weight loss, and was associated with elevated body temperature
Although not studied, topiramate treatment or an interaction of concomitant topiramate and valproic acid treatment may exacerbate existing defects or unmask deficiencies in Topiramate tablets can be taken without regard to meals
A proposed mechanism is an increase in reactive oxygen species (ROS) and oxidative stress
Discussion
Topiramate is a broad-spectrum antiepileptic drug approved for use in focal and generalized seizures 1, obesity management (with phentermine) 2, migraine prophylaxis 1, and is also frequently prescribed off-label for substance abuse disorders 3–5 and mood disorders 6,7
The median average daily dosages were 47
However, various antiepileptic agents have
A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase (CK) elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed to certain drugs []
Abstract
Change in
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling)
Perampanel has not been applied in MERRF patients but is promising in non-mitochondrial myoclonic epilepsy
Shah * Mitochondrial CA VA; Topiramate Received: March 31, 2015; Accepted: May 04, 2015; Published: May 20, 2015