muscle tightness
Amitriptyline has been reported to induce long QT syndrome and Brugada syndrome (see PubMed link)
Antidepressants: Amitriptyline, imipramine, citalopram, amitriptyline
Long QT syndrome is a heart rhythm disorder caused by changes in the heart's electrical recharging system
risk of serotonin syndrome, CNS depression, psychomotor impairment, altered BP
Nortriptyline, a second-generation tricyclic antidepressant, is an active metabolite of amitriptyline
8 Experience in long QT syndrome indicates that for every 10 ms increase in QTc there is a 5% increase in the risk of arrhythmic events
yellowing of the skin or eyes
Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome
This can lead to torsade de pointes ventricular
Amitriptyline belongs to a group of medicines known as tricyclic antidepressants
Safety of amitriptyline in pregnancy has
psy
Case reports identify amitriptyline and maprotiline as the tricyclic antidepressants most likely to provoke torsade de pointes
Sometimes, you may also feel confused or disoriented
Symptoms of overdosage may include dry mouth, coma of varying degree, hypotension, hypothermia, hyperreflexia, extensor plantar responses, convulsions, respiratory failure, cardiac conduction defects, and arrhythmias
Do not stop taking Amitriptyline after 1 or 2 weeks just because you feel it is not helping your symptoms
Most medicines used to treat nerve pain (also called neuropathic pain) were originally developed to treat other conditions
Generic amitriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower
There is some speculation and confirmation to an extent about the link between some tricyclic anti-depressant drugs and the prolonged QT interval, torsades de pointes, ventricular fibrillation and sudden cardiac death
Divalproex (Depakote), topiramate (Topamax), metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered as first-line treatment
These common side effects of amitriptyline happen in more than 1 in 100 people
The usual dose for an adult is 75 mg of amitriptyline a day in divided doses
For example, citalopram 20 mg daily has been shown to cause a mean change in baseline QTc of 7
Dry or sore mouth
Amitriptyline has a half-life ranging from 10 to 28 hours