Hydrochlorothiazide mode of action

This activity outlines the indications, mechanism of action, dosing, important adverse effects, contraindications, monitoring, and toxicity of HCTZ and increases practitioners' knowledge regarding how to approach this medication The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. It is chemically designated as 6-chloro-3,4-dihydro-2 H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and it has the following structural formula: Hydrochloro­thiazide USP is a white, or practically white, crystalline powder which is In addition, if sodium loss was the major mechanism of TPR reduction, one would expect kidney function to be necessary for thiazide-induced antihypertensive effects, as the kidneys are the primary organ responsible for sodium excretion

2024-03-29
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  1. Treatment
  2. Brand Names
  3. Thiazides do not affect normal blood pressure
  4. A
  5. 1–0
  6. As angiotensin II is a vasoconstrictor
  7. High blood pressure adds to the workload of the heart and arteries
  8. Mechanism of action
  9. Mechanism of Action