1016/j
Abstract
Identification of a thermodynamically stable polymorph is an important
The most widely known and well-known example in the history of the pharmaceutical
recognized that molecular level understanding of nucleation of polymorphs is necessary to control crystallization of polymorphs and comprehend the issues relevant to physical stability
Ritonavir (RIT) is a well-known case where the most stable polymorph II emerged after being marketed, leading to a loss of $250 million
Ritonavir (RIT) is a well-known case where the most stable polymorph II emerged EMA’s human medicines committee (CHMP) has issued advice on the use of Paxlovid (PF-07321332 and ritonavir) for the treatment of COVID-19
DOI: 10
This new polymorph was unexpectedly discovered to crystallize from melts as a major phase as we tried to search for the kinetically hindered polymorph II
On the basis of the results of 245 polymorph screens, organic compounds were found to exist in multiple solid forms quite frequently
Saudi Pharmaceutical Journal
The contents of the capsules were examined by microscopy
The disappearance of metastable polymorphs remains a mysterious phenomenon, and the lack of control over it can be frustrating and costly for drug development
The case study of Ritonavir Issues highlighted with the new Form II were dissolution test failures of the formulated product and a change in the morphology of the drug substance which impacted on the crystallization behaviour and caused higher levels of impurities and residual solvent A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy and thermal analysis
Org
Many synthesis Ritonavir, an antiretroviral drug of the protease inhibitor class used to treat HIV-1 infections, was found to have polymorphism that strongly impacts on solubility and dissolution rate
Ritonavir was found to exhibit conformational polymorphism with two unique crystal lattices having significantly different solubility properties