It is used as an antidote for overdose of digoxin
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106-139 (1981), disclose assays for digoxin that are based on a latex agglutination inhibition technique
Fab
Toxicity due to acute over-ingestion of digoxin is generally mild and manageable but can be life-threatening
Because life-threatening digitalis intoxication is unusual in children, treatment with digoxin-specific—antibody Fab fragments (Fab) has rarely
1097/MEJ
Treatment and management
PO (Children 5–10 yr): Loading dose: 20–35 mcg/kg given as 50% of the dose initially and one quarter of the initial dose in each of 2 subsequent doses at 6–12 hr intervals
5 mg/mL) in 9
5 mcg) intradermally and observing for an urticarial wheal surrounded by a zone of erythema
The half-lives of both digoxin and digoxin-Fab are prolonged in renal failure to over 100 h
If cardiac arrest is imminent, DIGIFab can be given by bolus injection
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Administer the dose
Wherein 0
Digoxin is one of the oldest medications used in the field of cardiology
You can also Publication number: 20160039917
Drug
An echocardiogram reveals an atrioventricular block
For intravenous infusion ( Lanoxin ®), give intermittently in Glucose 5% or Sodium chloride 0
3
Asystole or symptomatic high-degree atrioventricular block
In 1976, antibody fragments were first used successfully to treat patients []
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Table 1 Approximate Dose of DIGIFAB for Reversal of a Single Large Digoxin Overdose