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If you have stomach upset, you may take this medication with or after a meal or
Get emergency medical help if you have signs of an allergic reaction (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or
1 head-to-head study in adults
If any of these effects last or get worse, tell your doctor or pharmacist promptly
Before taking
Medical Answers
For oral dosage form (sustained-release tablets): For depression: Adults—At first, 150 milligrams (mg) once a day in the morning
Initiate dosing with 150 mg/day given
Bupropion can also cause seizures in a regular drinker who suddenly stops drinking at the start of treatment with bupropion
sore throat
Bupropion hydrochloride extended-release tablets (SR) may be taken with or without food
2 Dosage for Major Depressive Disorder (MDD) The recommended starting dose for MDD is 150 mg once daily in the morning
You should space Wellbutrin IR doses out by at least 6 hours, and space Wellbutrin SR doses out by at least 8
Bupropion is metabolized to three active metabolites once in the body, each with varying durations of action
The recommended starting dose is 200 mg per day, given as 100 mg twice daily
For ADHD, clinical trials suggest that a dose of between 150 mg and 450 mg per day can be helpful
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Wellbutrin XL comes in 150 mg and 300 mg tablets
It increases norepinephrine and dopamine in the brain, hormones that help regulate mood
Wellbutrin SR is only approved to treat depression
Depression and SAD
Psychological symptoms: Mood swings, agitation, anxiety, mania, and/or depression
Typical doses of bupropion (450 mg per day or less) are not as likely to cause seizures as higher doses