Among the glycols, propylene glycol has the lowest toxicity
due to high
Propylene glycol is metabolized to lactic acid (lactate) and has the potential to cause an anion gap, metabolic acidosis, especially in patients receiving prolonged infusions
Propylene glycol toxicity may mimic sepsis with septic shock by causing lactic acidosis and hypotension
61 Barbiturates are known to have negative ionotropic effects on cardiac contractility and tone that causes reduced cardiac index, cardiac output, and
Propylene glycol (PG) is a water-soluble alcohol that serves as a solvent in a variety of intravenously administered drugs in the intensive care unit and the general medicine ward
1 Structures 1
To prevent propylene glycol toxicity, appropriate dosing and monitoring are important
Fosphenytoin is rapidly and completely absorbed after intramuscular or intravenous administration
4 It is commonly used as a solvent for substances which are not soluble in water such as phenobarbital, glibenclamide, phenytoin, diazepam and injectable multivitamin
2009]
Excessive generation and GI absorption of D-lactate usually develop in patients with a variety of “short-gut” abnormalities such as jejunoileal bypass or s/p extensive small-bowel resection
3,5 Five common mechanistic groups
Glycerin; Pentylene Glycol (MinaCare® Pentiol Green by Minasolve) 1,3 Butylene Glycol; Propanediol (Zemea® by Tate and Lyle) Sodium PCA (AJIDEW® NL-50 by Ajinomoto) Sodium-L-Lactate (PURASAL® S/HQ60 by
Lactate is the end product of anaerobic glycolysis
Propylene glycol (PG) is often applied as an excipient in drug formulations
The area test, the Van Ness test, and pure component consistency test were used to check the VLE data’s
The book explains the differences between the E-series and the P-series, and how they are related to various industrial and consumer products
GOLD MARK
Extravasation of the solution may cause skin irritation or phlebitis