To investigate the pharmacokinetics of the new MOS formulation versus the marketed meclizine oral tablet (MOT), a phase 1 pharmacokinetic study was performed in 20
15 Meclizine has an onset of action of about one hour with a prolonged duration of action;
Pharmacokinetics (PK) after a single dose of meclizine 2 mg/kg in mice revealed that the maximum drug concentration (C max ) and area under the curve (AUC)
It increases CYP3A4 mRNA expression, but decreases CYP3A-catalyzed testosterone 6β
Pharmacokinetic analyses demonstrated that peak drug concentration (C max) and area under the concentration-time curve (AUC) of 2 mg/kg of meclozine
fluphenazine increases effects of meclizine by pharmacodynamic synergism
As meclizine undergoes metabolism, hepatic impairment may result in increased systemic exposure of the drug
However, the onset of action of meclizine was about 1 hour for the treatment of motion sickness and vertigo
To investigate the pharmacokinetics of the new MOS formulation versus the marketed meclizine oral tablet (MOT), a phase 1 pharmacokinetic study was performed in 20 healthy volunteers
Pharmacokinetics of Meclizine HCl pellet formulations
The effect of renal impairment on the pharmacokinetics of meclizine has not been evaluated
Hmmm… think about that for a Pharmacokinetics The available pharmacokinetic information for meclizine following oral administration has been summarized from published literature
Antivert (meclizine HCl) is an antihistamine used to treat nausea and vomiting associated with motions sickness and vertigo
Meclizine Hydrochloride, USP is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs
-MECLIZINE-Contraindications/Cautions
Because of a potential for drug/metabolite accumulation, meclizine hydrochloride should be administered with caution in patients with renal impairment and in the elderly, as renal function generally declines with age
It may also be used in the treatment of dizziness, vertigo, and labyrinth disorders
This activity illustrates the indications, action, and contraindications for phenothiazine as a valuable agent in
This study predicted the potential impact of CYP2D6 genotypes on the meclizine pharmacokinetics, although further study needs to be conducted to verify the simulation results
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