CrCl 10 to 29 mL/min: 500 mg orally twice a day for 1 day; the 2 doses should be administered 12 hours apart
Uncomplicated course: 800 mg orally 5 times a day for 5 to 7 days (alternative therapy; oral valacyclovir or famciclovir are preferred therapy) 2
Acyclovir (9- [2-hydroxymethyl]guanine) is a nucleoside analog that
Genital HSV-2 infections can be diagnosed with a physical exam, blood
Of all the human herpesviruses, acyclovir has the greatest in vitro activity
For cold sores caused by recurrence of the oral herpes simplex virus, early
The usual dose is 20 Among HSV-2-susceptible men, only age ≤30 years was associated with increased risk of HSV-2 acquisition (P =
HSV infections in the neonatal and pediatric populations range from uncomplicated mucocutaneous diseases to severe, life
Although valacyclovir will not cure shingles or genital herpes, it does help relieve the pain and discomfort and helps the sores heal faster
Herpes simplex - genital: Summary
(IV) acyclovir for herpes simplex virus type 1 (HSV-1) encephalitis [HIV], 3 with diabetes mellitus, and 2 on high-dose corticosteroids)
3 to 4
Herpes simplex viruses (HSVs) are double-stranded, enveloped DNA viruses
3 to 4
500 mg every 12 hours
If acyclovir is not available, use ganciclovir IV 6 mg/kg/dose every 12 hours
Viral infections of the central nervous system (CNS) result in the clinical syndromes of aseptic meningitis or encephalitis [ 1-3 ]
Within a randomized trial of daily acyclovir 400 mg twice daily in African HIV-1 serodiscordant couples, in which the HIV-1–infected partner was HSV-2 seropositive, we identified partnerships in which HIV-1–susceptible partners were HSV-2 seronegative to estimate the effect of acyclovir on risk of HSV-2 transmission
Effective pritelivir therapy in recurrent genital herpes in an immune-compromised allo-SCT recipient infected with acyclovir-resistant HSV-2 has been described
Herpes simplex iritis is due to the Herpes simplex virus, a double-stranded DNA virus