Over 85% of an intravenous dose is excreted in urine within 24 hours compared with approximately 50% for an oral dose
Atenolol excretion would be expected to
Atenolol is a hydrophilic betareceptor blocking drug, which is predominantly eliminated via the kidneys, only about 5% of the atenolol is metabolised by the liver
Atenolol may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level
With 85% renal excretion, atenolol presents a high risk for accumulation in infants, especially neonates
Unlike propranolol or metoprolol, but like nadolol, atenolol undergoes little or no metabolism by the liver, and the absorbed portion is eliminated primarily by renal excretion
Feb 20, 2015 · In conclusion, our results showed that atenolol can inhibit the renal excretion of metformin via down-regulating rMate1 expression in the kidney of rats; long-term atenolol treatment can cause persistent increase of plasma metformin concentration, which may increase the risk of lactic acidosis
No significant accumulation of TENORMIN occurs until creatinine clearance falls below 35 mL/min/1
Treatment of HTN alone or in conjunction with others; management of angina pectoris; post-MI
Amount of atenolol excreted daily in breast milk for 2–4 weeks (n=32), 3–4 months (N=22), and 6-8 months (n=15) postpartum
Atenolol is excreted by the kidneys; consequently dosage should be adjusted in cases of severe impairment of renal function
Accumulation of atenolol and prolongation of its half Because of atenolol's relatively extensive excretion into breastmilk and its extensive renal excretion, other agents may be preferred while nursing a newborn or preterm infant or with high maternal dosages
10
In patients with normal renal function the atenolol half-life was calculated to be about six hours following single 100 mg Despite the critical role of the kidney in atenolol disposition, the molecular mechanisms involved in the renal handling of atenolol have not been well understood
7 By contrast, calcium channel blockers increase urinary calcium excretion and may lead to a Feb 16, 2024 · Renal impairment
In patients with impaired renal About 50% of administered atenolol is absorbed; however, most of the absorbed quantity reaches the systemic circulation
Sodium channel blocking beta-blockers are said to possess “membrane stabilizing activity” which
A significant positive correlation was found between the changes in CO and in systolic blood pressure (SBP) while negative correlation was observed between Sep 30, 2022 · Evaluation of patients with hypertension or myocardial infarction should always include assessment of renal function
The presence of slightly increased urinary albumin excretion (UAE), even at levels well below levels detectable by an ordinary dipstick, has been suggested as a predictor of cardiovascular morbidity and as a reflection of the degree of overall vascular permeability
0 micrograms/kg/min) infusion
Reductions in resting heart rate and arterial blood pressure were proportional to either the logarithm of dose or area under the plasma concentration time curve or cumulative urinary atenolol excretion
Atenolol also differs from propranolol in that only a small amount (6% In fact, all excretion may be dependent upon the kidney, yet no unchanged drug is detected in urine at all