It was originally used as a bronchodilator but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely used
1 mmol/kg) or an equivalent volume of saline
) injection, whereas steady state CSF and brain concentrations of L-glucose were not approached until after 5 h
The results in vivo showed that there were no significant effects on the CL and AUC of both total and unbound theophylline in rats treated with dosage regimen A of baicalin
What Is Theophylline? Theophylline is a prescription medication that helps widen the airways to improve the flow of air into the lungs
To get this same amount from chocolate, your rat would have to eat a lot
Theophylline (anhydrous) Extended-Release Tablets in a controlled-release system allows a 24-hour dosing interval for appropriate patients
Ten days of However, the patient can still experience side effects with this drug
In 13 week toxicity studies, theophylline was administered to F344 rats and B6C3F1 mice at oral doses of 40-300 mg/kg (approximately 2
After addition of ammonium sulfate to the samples, theophylline is extracted from the plasma into chloroform
The amount of exhaled breath of rats was estimated by the amount of exhaled water vapor, and the drug concentration in exhaled breath sample was expressed by the amount of water vapor as the denominator
v
Theophylline is used as a bronchodilator in dogs and cats with asthma or other respiratory conditions
At the high dose, systemic toxicity was observed in both species including decreases in testicular weight
Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory diseases, alone or in combination with other drugs
Co-administration of 25-D3 with theophylline completely abrogated theophylline-induced osteopenia and alterations in calcium homeostasis
Materials and methods: The study was a randomized, three-period crossover design
The whole body autoradiography study in rat showed that the concentration of radioactivity in In contrast, in rats the theophylline is metabolized to 1,3-dimethyluric acid via CYP1A2 and CYP2E1 and to 1-methylxanthine via CYP1A2 which was further metabolized to 1-methyluric acid via xanthine oxidase (Teunissen et al
(1982), 75%,451-454 EFFECTS OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON SCHEDULED CONTROLLED RESPONDING IN RATS JOHN M
A
The types of hepatic cytochrome P450 (CYP) isozymes responsible for the metabolism of theophylline and for the formation of 1,3-dimethyluric acid (1,3-DMU) in rats in-vivo does not seem to have been studied at the dose ranges of dose-independent metabolic disposition of theophylline in rats (up to 10 mg kg(-1))
Gravid rats were injected with LPS or saline into the amniotic sacs at E16
Rats, Wistar Theophylline / therapeutic use Marked reduction of colon inflammation, ulcers, colitis score and body weight loss were seen after administration of theophylline especially at medium (25 mg/kg) and high (50 mg/kg) doses
This study investigates effects of Andrographis paniculata extract (APE) and its major component, andrographolide (AG), on the pharmacokinetics of theophylline, a typical substrate of cytochrome P450 1A2 enzyme, in rats
Methods: Rat epitrochlearis muscles and soleus strips were incubated with insulin and different concentrations of caffeine and theophylline for measurement of glucose uptake, force development and PKB phosphorylation
The retention time of theophylline was 5
Chloramphenicol treatment, 75 mg/day intravenously for 3 days, significantly (p less than 0
A bronchodilator, aminophylline is a derivative of theophylline
The gastrointestinal (GI) transit and absorption of orally administered theophylline, a highly absorbable drug without presystemic elimination, were investigated under fasted and fed conditions using three rats in a crossover study
See more Reproductive toxicity: Feeding theophylline to immature (five to six weeks old) Osborne-Mendel rats at 0
Theophylline treated rats exhibited a significant decrease in hepatic vacuolation, apoptosis, leucocyte infiltration, and accumulation of collagen fibers in
The half-life of theophylline in rat was said to about 70 min with dosing less than 11 mg kg –1, and 4 h above 100 mg kg –1
Erythrocyte:plasma ratios for theophylline in neonatal rats were also significantly higher than ratios in adult rats
Theophylline was administered by gavage in 13-week studies to B6C3F1 mice (0, 75, 150, 300 mg/kg/day) and F344 rats
Theophylline (brand names: Theo-24®, Theochron®, Elixophyllin®, Theodur®) is a bronchodilator used to treat coughs caused by bronchospasm or
An accurate and reproducible high performance liquid chromatographic assay for theophylline in rat plasma has been developed
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In 13 week toxicity studies, theophylline was administered to F344 rats and B6C3F 1 mice at oral doses of 40 to 300 mg/kg (approximately 2 times the human dose on a mg/m² basis)
2, 0
, theophylline or aminophylline), or with nebulized treatments of gentamicin and/or albuterol in normal or 7% saline
It opens the lung’s air passages by relaxing the muscles Herb–drug interaction has become a serious problem since herbal medicine is extensively used in the modern world
The methylxanthines, particularly theophylline, are bronchodilators ( see Table: Methylxanthine Bronchodilators Methylxanthine Bronchodilators )
However, after four to eight hours the slope of the curves d
Typical chromatograms of theophylline in rat blood and brain are shown in Fig
The calibration graph of theophylline was obtained prior to LC analysis of dialysates over concentration range of 0
Aim of the study: To elucidate the effect of baicalin on the pharmacokinetics of theophylline in rats, focusing on plasma protein binding displacement and inhibition effect on CYP1A2 in vivo and in vitro
The pharmacokinetic parameters of theophylline indicated that pretreatment of rats with GBE at daily dosages of 10 mg/kg and 100 mg/kg for five consecutive days resulted in a 20
The elimination half-life of theophylline was Theophylline is mainly metabolized by CYP1A2, so the changes in pharmacokinetic parameters can also reflect the effect of baicalin on CYP1A2
(1982), 75%,451-454 EFFECTS OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON SCHEDULED CONTROLLED RESPONDING IN RATS JOHN M
The types of hepatic cytochrome P450 (CYP) isozymes responsible for the metabolism of theophylline and for the formation of 1,3-dimethyluric acid (1,3-DMU) in rats in-vivo does not seem to have been studied at the dose ranges of dose-independent metabolic disposition of theophylline in rats (up to 10 mg kg(-1))