Stopping the drug (s) causing serotonin DEFINITION Serotonin syndrome (ie, serotonin toxicity) is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system
Cyproheptadine may be used as an antidote
OBJECTIVE:T o report a psychiatric patient who developed serotonin syndrome after a medication overdose and whose marked mydriasis was quickly reversed by administration of cyproheptadine
PDF Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine
METHOD: In the index patient as well as in three subsequent cases of serotonin syndrome, pupil diameter, muscle tone, mental status, and vital signs were monitored before and after a test dose The serotonin syndrome is the result of excess stimulation of central nervous 5-hydroxytryptamine (5HT)-1a and 5HT-2 receptors
1 Despite the common use of medications with direct or indirect serotonergic effects, many physicians are not aware of the presentation and management of serotonin excess
Section snippets Discussion
Dextromethorphan (DXM) is used to treat colds and coughs; however, it can cause central nervous system symptoms, such as severe serotonin syndrome (SS)
Serotonin-production blocking agents
Serotonin syndrome: early management Serotonin syndrome is a potentially preventable, medication-related complication that occurs from increased serotonin activity in the central nervous system, usually secondary to the use of one or more serotonergic agents
Chan BS, Graudins A Use of Cyproheptadine for the Treatment of Serotonin Syndrome: A Case Series
This report describes the use of cyproheptadine for the management of serotonin syndrome in a patient taking fluoxetine and bupropion, who received methylene blue for vasoplegia syndrome
Results and discussion
Specifically, it acts to block 5-HT1A and 5-HT2A receptors, which are the receptors responsible for the symptoms of serotonin syndrome
Cyproheptadine is only available in oral form
Serotonin syndrome is observed across the full range of age groups, from neonates all the way through to the elderly, with an increasing incidence likely to represent the increasing use of serotonergic drugs in clinical practice
Although classically described as the triad of mental status changes Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs
The serotonin syndrome (SS) is a potentially life-threatening drug interaction caused by excessive serotoninergic activity in the CNS
It can arise from therapeutic drug use, drug interactions, or intentional overdose of medications that affect the serotonergic system
Cyproheptadine is an antagonist at muscarinic, H-1 histaminic and serotonergic receptors
Ann Pharmacother
Unsuspected Diagnosis of serotonin syndrome Onset of serotonin syndrome is usually within a few hours of drug initiation or dose changes and diagnosis of serotonin syndrome is primarily clinical
Ann Pharmacother
Serotonin syndrome typically results from the increased intrasynaptic concentration of serotonin or 5-hydroxytryptamine (5-HT)
3
Presence of 'lead pipe' rigidity is typical of NMS, while serotonin syndrome typically manifests with tremor and hyperreflexia
McDaniel WW
Ann • Serotonin syndrome • Cyproheptadine Ovid: Medline 1946- june week 4 2017 (exp Serotonin Syndrome/ OR serotonin toxicity
Untreated, serotonin toxicity can progress to multi-organ failure and death
1998;16(4):615-9
60 Positron emission Conclusion: With the increasing use of serotonergic agents, awareness of serotonin syndrome is important
Am Fam A Case of Serotonin Syndrome Following Cyproheptadine Withdrawal
The majority of these patients received cyproheptadine at an initial dose of 8 mg, while fewer patients responded to as little as 4 mg and some had
Patients with moderate or severe cases of serotonin syndrome require hospitalization
Serotonin syndrome (SS) is an often undiagnosed and potentially life-threatening adverse drug reaction caused by excessive activation of postsynaptic
The management of serotonin syndrome relies upon its early recognition and the initiation of supportive care in the Emergency Department
The diagnosis requires a history of
Serotonin syndrome is a potentially life-threatening condition that occurs when you take medications that affect serotonin levels
The benefits of and indications for cyproheptadine are uncertain and questionable for the management of a serotonin syndrome
A 61-year-old female taking fluoxetine and bupropion preoperatively was given a total of three doses of methylene blue 100 mg IV within a brief
Serotonin syndrome: early
Serotonin syndrome is a potentially preventable, medication-related complication that occurs from increased serotonin activity in the central nervous system, usually secondary to the use of one or more serotonergic agents
Cyproheptadine (4 mg tid) for 3 wk
Pharmacologically directed therapy involves the administration of 5-HT 2A antagonists
Section snippets Discussion
It is seen with therapeutic medication use, inadvertent interactions between drugs, and intentional self-poisoning []
Management consists of immediate discontinuation of serotonergic agents, hydration, and supportive care to manage blood pressure, hyperpyrexia, and respiratory and cardiac complications
2; References
The patient was taking multiple serotonergic agents and required the use of linezolid without the possibility of a sufficient washout period
McDaniel WW
J Clin Psychopharmacol
Serotonin syndrome can be a life-threatening condition that occurs from the overactivity of serotonin in the central nervous system
Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever
Lane R, Baldwin D
Article CAS PubMed Google Scholar Graudins A, Stearman A, Chan B
Specifically, it acts to block 5-HT1A and 5-HT2A receptors, which are the receptors responsible for the symptoms of serotonin syndrome