Colchicine is a very old, inexpensive treatment
5 to 3 heart attacks or other events for every 100 patients
7%) patients
Anakinra—recombinant IL-1 receptor antagonist—has also shown to have promising effects in blunting the acute inflammatory response in acute MI and improving cardiorespiratory fitness in patients with heart failure and high-sensitivity C-reactive protein ≥ 2 mg/L
Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders
5 mg once daily) was associated with a 25% relative risk reduction of major recurrent CV events
21 to 0
Before addressing the clinical significance of the study by Deftereos and colleagues, it is useful to digress for a moment and discuss the biological plausibility of the use of colchicine in this patient population
Overdose symptoms may include diarrhea, nausea, vomiting, stomach pain, muscle weakness, little or no urinating, numbness or tingling, weak pulse, slow heart rate, weak or shallow breathing, or fainting
The 0
However, not all the drugs used in gout treatment improve CV outcomes; colchicine has shown improved
Certain medications for blood pressure, heart disease, irregular heart beat; Certain medications for cholesterol like atorvastatin, lovastatin, and simvastatin; Colchicine is used by people with heart disease or people who have multiple risk factors for heart disease to help reduce the risk of getting serious related heart and blood vessel problems (such Lodoco (colchicine) is a medication that lowers the risk of stroke and heart problems in adults with risk factors for heart disease
It showed that colchicine may provide substantial benefit and reduce the risk of myocardial infarction in secondary CVD prevention, as indicated by a statistically significant dose effect of colchicine on all‐cause mortality in favour of lower‐dose treatment (i
Colchicine, originally extracted from the autumn crocus ( Colchicum autumnale ), is a widely available drug that is commonly used to treat gout, familial Mediterranean fever, and pericarditis
Sue Hughes
For years, colchicine has been used as a safe and well-tolerated agent in diseases such as gout and familial Mediterranean fever