In patients that develop severe
Symptoms can include: trouble
Acyclovir nephrotoxicity has been described since the inception of the drug's use more than a decade ago
As per RIFLE classification, renal injury was graded as either at risk of renal dysfunction (62
Intravenous acyclovir-induced acute kidney injury (AKI) from drug crystallization in the renal tubules is described in case reports, review articles, and drug prescribing manuals
Acyclovir-associated nephrotoxicity can be minimized in both populations by ensuring adequate hydration, maintaining a high urine flow, and administering ACV at a
The pharma companies are competing to develop treatments for IgAN, which is a progressive autoimmune disease that mostly affects young adults and which can lead
Acyclovir can produce kidney failure either through precipitation within the tubular lumen or from acute interstitial nephritis
5 hours in normal renal function to 2 years or older (over 40 kg): 800 mg orally 4 times a day for 5 days
Treatments for overt acute renal failure (ARF) caused by acyclovir include drug withdrawal, diuresis using loop diuretics, adjustment of medication dose, a restricted diet, metabolic and volume management, and dialysis to allow for metabolic and volumetric control and removal of acyclovir
No clear recommendations, but adjustment probably not necessary (<1% renal elimination) Pyrazinamide Adult 20-25 mg/kg PO q24h (Round to 500mg tablet) 40 to 55 kg: 1,000 mg once daily 56 to 75 kg: 1,500 mg once daily CrCl <30 or HD: 25-35 mg/kg three times weekly
A more plausible explanation might be his risk factors for renal failure
The combined data from these patients support crystalluria and obstructive nephropathy as a mechanism of acyclovir-induced renal failure in humans
Acute renal failure mediated by this compound is characterized by abrupt elevations in serum creatinine and a gradual return to baseline renal function on discontinuation of the drug
This study reports the case of a patient with renal dysfunction who suffers from acute herpes zoster (shingles) on her back
Clinical manifestations range from mild forms
The temporal relationship between the initiation of oral acyclovir therapy and the onset of adverse events, supported by published data of a few similar cases, strongly implicate oral acyclovir as the cause of this patient's acute renal failure and The drug crystallizes in the renal tubules causing damage
Chronic kidney disease was defined according to KDIGO CKD criteria
Although this feature may confer more potent activity, it may also increase the risk of renal toxicity due to precipitation of acyclovir crystals in the renal tubules (see "Crystal-induced acute kidney injury")
Proper Use
Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function: a case
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in immunocompromised patients