d
Clindamycin is administered by intravenous (IV) intermittent infusion over at least 10 to 60 minutes at a maximum rate of 30 mg/minutes
The National Quality Forum’s National Quality Partners Playbook on Antibiotic Stewardship in Acute Care identifies IV to PO change as a patient-specific intervention for intermediate programs
IV-PO= high oral bioavailability – Consider IV to PO
Solution for injection Vaginal cream Liquid Cutaneous gel Drug action For clindamycin With systemic use: All three salt forms of clindamycin: clindamycin phosphate, clindamycin hydrochloride, and clindamycin nicotinamide have the same antimicrobial spectrum and
2 g day −1 in two, three or four equal doses for serious infections and for more severe
3
No renal dose adjustment: Necrotizing Soft Tissue Infection & Group A Streptococcus Infection, Pelvic Inflammatory Disease: 900 mg IV Q8h: Next: Antibiotics
Oral bioavailability and pharmacokinetic behaviour of clindamycin in dogs was investigated following intravenous (IV) and oral (capsules) administration of clindamycin hydrochloride, at the dose of 11 mg/kg BW
900 mg IV every 8 hours with gentamicin 2 mg/kg; PO: 300 mg orally every 12 hours for 7 days; Pneumocystis (carinii) jiroveci (Off-label) CRRT: 6mg/kg IV Q24h Alt: 8 – 10mg/kg IV Q48h
– bypass first pass metabolism in the liver
They are also usually less expensive
41/dose) Clindamycin 600mg IV every 8 hours ($12
These include (1) newer concepts of antimicrobial pharma-codynamic action and the realiza-tion that this can be achieved by oral agents, (2) the advent of newer, more potent, broad-spec-trum oral agents
Co-amoxiclav 375-625mg 8 hourly
The dosages for clindamycin capsules for adults are: for serious infections, 150–300 mg every 6 hours
Ciprofloxacin 500 mg PO BID + Clindamycin 600 mg PO TID
Oral options include penicillin V potassium, amoxicillin, cephalexin, and cefadroxil